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Risk of immune reconstitution syndrome if used in combination with other antiretroviral drugs.
Patients who interrupt nevirapine dosing for more than 7 days should restart the recommended dosing regimen using the two week lead-in period.
Boceprevir is partly metabolized by CYP3A4/5Co-administration of boceprevir with medicines that induce or inhibit CYP3A4/5 could increase or decrease exposurePlasma trough concentrations of boceprevir were decreased when administered with an NNRTI with a similar metabolic pathway as nevirapineThe clinical outcome of this observed reduction of boceprevir trough concentrations has not been directly assessed.
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